A tragic chain-reaction crash on an Ohio highway involving a charter bus, a tractor-trailer, and three other vehicles left six people dead and 18 injured.

Among the casualties, three students from the Tuscarawas Valley school district, aged 15 and 18, lost their lives, and 16 others, including the bus driver, sustained injuries.

The charter bus was en route to an education conference, carrying students and chaperones from eastern Ohio.

Injured individuals were promptly transported to nearby hospitals for treatment.

The collision occurred on Interstate 70 near Etna Township, about 21 miles east of Columbus, involving a total of five vehicles.

At least three of the vehicles, including the bus, caught fire, intensifying the severity of the incident.

Authorities are investigating the cause of the crash, and details about the sequence of events leading to the tragedy remain undisclosed.

The Ohio School Boards Association convention, where some students were scheduled to perform, was canceled following the devastating accident.